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KMID : 0545120030130010043
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Journal of Microbiology and Biotechnology
2003 Volume.13 No. 1 p.43 ~ p.49
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Biotransformation of a Fungicide Ethaboxam by Soil Fungus Cunninghamella elegans
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PARK, MI-KYOUNG
LIU, KWANG-HYEON/LIM, YOONGHO/LEE, YOUN-HYUNG/HUR, HOR-GIL/KIM, JEONG-HAN
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Abstract
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Metabolism of a new fungicide ethaboxam by soil fungi was studied. Among the fungi tested, Cunninghhamella elegans produced metabolites from ethaboxam, which were not found in the control experiments. M5, a major metabolite from ethaboxam, was firmly identified as N-deethylated ethaboxam by LC/MS/MS and NMR. N-Deethylated ethaboxam has been found as a single metabolite in in vitro metabolism with rat liver microsomes. M1 was proved to be 4-ethyl-2-(ethylamino)-1, 3-thiazole-5-carboxamide (ETC) by comparing with the authentic compound. In addition, M2, M3, and M4, and M6 were tentative identified by LC/MS/MS as hydroxylated and methoxylared ethaboxams, respectively. Production of the major metabolite, N-deethylated ethaboxam, by the fungus suggested that C. elegans would be an efficient eukaryotic microbial candidate for evaluating xenobiotic-driven mammalian risk assessment.
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